GLP-1s: Staying On, Coming Off, & What to Expect

In this in-depth episode of 'Getting Better with Jonathan Van Ness,' host JVN dives into the world of GLP-1 medications with Dr. Kazarian, a compassionate family physician and advocate for holistic, preventive care. The conversation unpacks how GLP-1s work in the body—mimicking natural hormones to reduce hunger and food noise—while emphasizing that they’re not a magic fix but part of a broader framework that includes nutrition, movement, and mental health. JVN shares his personal journey with GLP-1s, from initial hesitation to finding success with Zepbound, and discusses the nuances of maintenance dosing, side effects like nausea and constipation, and the importance of protein and fiber intake. Dr. Kazarian stresses that obesity is a chronic condition requiring long-term management, and that stopping medication doesn’t mean failure—especially when supported by lifestyle changes. The episode also critiques the U.S. healthcare system’s underfunding of family medicine and the high cost of GLP-1s, advocating for universal healthcare and systemic reform. Ultimately, the message is one of empowerment: it’s okay to seek help, and weight loss should be approached with compassion, not shame.