If it works, why can’t doctors prescribe cannabis?
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This episode of USA Today's The Excerpt explores the paradox of cannabis: a substance with centuries of medical use that remains classified as a Schedule I drug in the U.S., despite growing evidence of its therapeutic value. Dr. Stacey Gruber, a leading expert in cannabis neuroscience, explains how cannabis was once a legal prescription medication in the 19th century before being criminalized in 1970. She highlights the pivotal role of Charlotte Figge, a child with a rare, severe epilepsy, whose dramatic improvement on CBD-rich cannabis sparked a national movement and led to the FDA approval of Epidiolex. Dr. Gruber discusses her MIND program at McLean Hospital, which conducts longitudinal studies on medical cannabis use, emphasizing the importance of personalized treatment, product formulation (whole plant vs. isolate), and the need for rigorous clinical trials. The episode underscores the critical distinction between recreational and medical use, challenges the myth that all cannabis causes intoxication, and advocates for evidence-based, patient-centered approaches to cannabinoid therapies.
Cannabis was once a legal prescription drug in the U.S. and has a long history of medical use, but remains in Schedule I due to outdated classifications.
Charlotte Figge’s story was a turning point in medical cannabis advocacy, demonstrating that non-intoxicating CBD can dramatically reduce seizures in pediatric epilepsy.
Whole plant, full-spectrum cannabis products may be more effective than isolated CBD due to the entourage effect, though more clinical trials are needed.
Medical cannabis is not one-size-fits-all—individual responses vary based on genetics, metabolism, and specific cannabinoid profiles.
Patients should know the cannabinoid and terpene content of their products and consult with healthcare providers to avoid drug interactions.
The Medical History of Cannabis
The episode opens with a historical overview of cannabis as a prescription medication in the U.S. dating back to 1850, before its criminalization in 1970 under the Controlled Substances Act.
Charlotte Figge and the CBD Revolution
“She became the face and the representation of people who... who could benefit from this.”
The MIND Program: Researching Medical Cannabis
“We really have a number of different initiatives designed to look at the impact of these unbelievably promising compounds for different indications and conditions.”
Whole Plant vs. Isolate: The Entourage Effect
“It's very likely you have a better clinical response at lower doses using a whole plant full or broad spectrum product.”
Personalized Medicine and the Future of Cannabis
Dr. Gruber emphasizes the need for personalized treatment, patient education, and continued research to unlock the full potential of cannabis therapies across conditions like anxiety, chronic pain, and neurological disorders.
“She became the face and the representation of people who... who could benefit from this.”
“It's when you have people who are suffering, and you have things to offer them that haven't previously been available, and it isn't likely to hurt but could certainly help, you certainly should give it a shot.”
“It worked from the very first dose. She stopped seizing.”
Host
Guest
Dr. Stacey Gruber
person
CBD
other
Charlotte Figge
person
THC
other
McLean Hospital
organization
MIND Program
other
Schedule I
other
Epidiolex
product
Paige Figge
person
Controlled Substance Act
other
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