Full Episode: Tuesday, April 21, 2026

ABC's World News Tonight with David Muir delivers a high-stakes, fast-paced broadcast covering multiple international and domestic crises. The episode opens with escalating tensions between the U.S. and Iran, as President Trump extends a ceasefire despite Iran’s refusal to negotiate unless the U.S. lifts its naval blockade—prompting military actions including the seizure of an Iranian oil tanker. Simultaneously, a shocking copycat attack at Mexico’s Teotihuacan pyramids, 27 years after Columbine, leaves 13 injured and one dead, with the shooter found carrying Columbine-related materials. In the U.S., a driver deliberately crashes into Philadelphia police headquarters, injuring five, while a near-collision at JFK Airport raises aviation safety concerns. On Capitol Hill, heated Senate hearings question Health Secretary Robert F. Kennedy Jr. over his handling of a measles outbreak and President Trump’s Fed nominee Kevin Warsh over alleged political pressure. FBI Director Kash Patel defends himself against allegations of alcohol-related absences with a $250 million defamation lawsuit. The episode also features a poignant tribute to Alan Osmond, the Osmond family’s patriarch, and a viral moment at the Boston Marathon where three strangers helped a struggling runner cross the finish line together. The broadcast closes with a powerful message of unity and resilience.