Total Bases | MLB Betting Picks Today! Wednesday Odds, Props & Best Bets | 4/22

In this episode of WagerTalk's Total Bases, hosts Brian Leonard, Tokyo Brandon (TB), and Adam discuss MLB betting picks for Wednesday, April 22, 2026, focusing on key matchups, pitching matchups, and prop bets. The team recaps a successful parlay from the previous night involving the Padres and evaluates their current record, still slightly negative but on a winning streak. They analyze the Yankees vs. Red Sox game, with mixed opinions on whether to back the Yankees despite Boston’s poor offensive performance. The Mets vs. Twins game draws strong discussion, particularly around rookie lefty Connor Prelip, who is seen as a potential value play due to his strong AAA performance and the Mets’ struggles against left-handed pitching. The Orioles vs. Royals game is deemed a low-scoring affair with weak bullpens on both sides, leading to cautious betting. A major theme is the evolving handicapping approach in early April, where bookmaker pricing is still adjusting to real-world performance. The hosts also highlight under-the-radar props, such as Didier Fuentes’ over strikeouts and outs, and discuss the impact of the World Baseball Classic on team performance. The episode concludes with a three-leg parlay: Mets team total under 4.5 (-140), Braves money line (-145), and Mariners money line (-185). Brian Leonard is traveling and will miss Friday’s show, but the team promises to return with more picks.