The Skincarma Pod | Ep. 73: NAD⁺ — The Molecule Everyone Wants to Boost, But No One Can Measure with Jari Närhi, NADMED CEO
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The guest, Jari Närhi, CEO of NAD Med, reveals a groundbreaking truth: for years, the longevity world has been chasing NAD+ supplementation without ever being able to measure whether it’s actually needed. Until now. NAD Med has developed the first clinically viable blood test to accurately measure NAD+ and its related forms—NADH, NADP, and NADPH—in real-world labs. This breakthrough exposes a critical flaw in the current wellness trend: most people are boosting NAD+ blindly, assuming they’re deficient, when in reality, NAD+ levels don’t reliably decline with age. Instead, chronic illness, inflammation, and disease are the real consumers of NAD+. The test, requiring a standard venous blood draw (not finger-prick or home kits), allows clinicians to assess true NAD status and avoid the risks of over-supplementation—like shutting down the body’s natural production. What’s more, measuring the full metabolic profile of these six NAD-related metabolites could one day become a diagnostic tool for conditions from cancer to neurodegenerative diseases. The episode ends with a powerful reminder: before chasing the next longevity trend, test first, supplement only when necessary.
NAD+ levels in blood do not decline with age—chronic illness and inflammation are the real drivers of depletion.
The first clinical blood test for NAD+ and its related metabolites is now available through partner labs in North America.
Home tests and finger-prick kits are unreliable for NAD+ due to the molecule’s extreme instability.
Over-supplementing NAD+ may cause the body to stop producing it naturally, leading to crashes when supplementation stops.
Measuring the ratio of NAD+ to NADH provides insight into cellular energy and metabolic health.
…and 3 more takeaways available in PodZeus
The NAD+ Obsession: Why No One Knows If They Need It
“Until recently, measuring NAD in the human body, especially in blood, has been incredibly difficult. The molecule is unstable. It degrades quickly, and for decades, reliable testing was largely confined to research labs.”
How NAD+ Works—and Why It’s So Hard to Measure
“NAD resides inside of cells. And in red blood cells, you have hemoglobin and all kinds of other things that make it complicated to get relevant signals. The NADs are deep inside the cells, wrapped in multiple layers of different proteins.”
The Real Reason NAD+ Levels Drop—and Why You Should Test First
“On the population level, older population tend to have lower NAD levels in their blood. But that's because of the fact that as you get older, you contract more chronic and acute illnesses and diseases. And those consume NADs.”
The Future of NAD Testing: From Blood Draw to Metabolic Fingerprinting
“The ratio of these two forms is, as one professor put it, is the language that the cells understand when they are directing the resources to catabolic and metabolic uses.”
The Risks of Blind NAD+ Supplementation and the Power of Balance
Jari warns against over-supplementing NAD+—it may suppress natural production, leading to energy crashes when stopped. He emphasizes that the body thrives on balance, not extremes. The episode closes with a call to prioritize foundational health: diet, exercise, and sleep.
“On the population level, older population tend to have lower NAD levels in their blood. But that's because of the fact that as you get older, you contract more chronic and acute illnesses and diseases. And those consume NADs.”
“Until recently, measuring NAD in the human body, especially in blood, has been incredibly difficult. The molecule is unstable. It degrades quickly, and for decades, reliable testing was largely confined to research labs.”
“The ratio of these two forms is, as one professor put it, is the language that the cells understand when they are directing the resources to catabolic and metabolic uses.”
Host
Guest
nad med
organization
jari närhi
person
carmine
person
niacin
other
university of helsinki
organization
type 1 diabetes
other
mexico city
place
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