Infectious Rheumatology (5.15.2026)

A groundbreaking study reveals that partial meniscectomies for degenerative knee tears offer no long-term benefit over sham surgery—raising serious questions about a decades-old orthopedic standard. Meanwhile, the podcast dives deep into infectious rheumatology, spotlighting chikungunya’s global reach and the surprising link between a common autoimmune gene (PTPN22) and enhanced protection against coronavirus. A major patient registry study debunks the myth that biologics increase non-serious infections, urging clinicians to continue treatment during minor illnesses. The episode also exposes a deadly combo: rheumatoid arthritis patients with non-tuberculous mycobacterial infections face a fourfold higher risk of respiratory death. In lupus, RNP antibodies—once considered benign—are now tied to worse disease activity, higher steroid use, and dramatically reduced remission rates. Finally, a promising new TLR7/8 inhibitor shows 50–70% better skin outcomes in lupus patients, potentially rivaling hydroxychloroquine’s safety and efficacy.