The Tate Chronicles: Dr Yana Aznavour, Endometrics
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In this episode of Healthcare NOW Radio's Tate Chronicles, host Jim Tate speaks with Dr. Yana Aznavour, CEO and founder of Endometrics, a company developing a groundbreaking non-invasive diagnostic test for endometriosis using menstrual blood. Currently in its final prospective clinical trial, the test aims to eliminate the current 10-year diagnostic delay by enabling at-home collection and lab analysis via a simple, stable kit. The technology leverages gene expression signatures detected through RT-PCR, achieving 92.3% sensitivity and 100% specificity in studies. Dr. Aznavour emphasizes the profound impact of delayed diagnosis—chronic pain, misdiagnosis (often as IBS), infertility, and psychological distress—while advocating for a shift in clinical workflow to prioritize early, accurate diagnosis. The test will require a prescription and is not intended as a screening tool but as a clinical diagnostic aid for women with pelvic pain or infertility. Endometrics is working toward insurance reimbursement and broader accessibility, with a commercial launch anticipated post-quarter next year. The episode underscores the transformative potential of menstrual blood as a diagnostic medium and the urgent need for innovation in women’s health.
Endometriosis diagnosis currently takes up to 10 years due to lack of non-invasive, reliable tests.
Endometrics' at-home menstrual blood test uses gene expression analysis (RT-PCR) with 92.3% sensitivity and 100% specificity.
The test will require a prescription and is designed for women with pelvic pain or infertility, not general screening.
Sample collection is simple—menstrual blood on a pad with stabilizing solution, mailed in a biohazard kit without refrigeration.
The technology could disrupt the current diagnostic workflow by decoupling diagnosis from surgery and reducing patient suffering.
…and 3 more takeaways available in PodZeus
Introduction to Endometrics and the Endometriosis Crisis
“No disease should be diagnosed within eight years. That's ridiculous to have such enormous diagnostic delay and just keep women suffering in silence.”
The Science Behind the Test: Menstrual Blood as a Diagnostic Window
Dr. Aznavour explains how menstrual blood—rich in reproductive biomarkers—serves as a biologically relevant sample for detecting endometriosis, with gene expression signatures validated across menstrual cycles.
How the Test Works: From Home Collection to Lab Results
The process is detailed: at-home collection on day two of menstruation, stabilization, mailing via prepaid biohazard kit, and central lab analysis with results delivered in under a week.
The Human Cost of Delayed Diagnosis
“Our patients experience pre-hormonal treatment anxiety, preoperative anxiety because the physician is not quite sure there is endometriosis.”
Clinical Workflow and the Path to Commercialization
The test will be prescription-only, integrated into clinical workflows, and targeted at providers who suspect endometriosis. Endometrics is building clinician education and seeking CPT code approval for insurance coverage.
“No disease should be diagnosed within eight years. That's ridiculous to have such enormous diagnostic delay and just keep women suffering in silence.”
“Our patients experience pre-hormonal treatment anxiety, preoperative anxiety because the physician is not quite sure there is endometriosis.”
“Science first, then you innovate, then you commercialize the test. That's why I decided to build a product around the good science that we had already.”
Host
Guest
Dr. Yana Aznavour
person
Endometrics
organization
Jim Tate
person
Cologuard
product
Blue Cross Blue Shield of Massachusetts
organization
American Association of Gynecological Laparoscopists
organization
GLP-1 medications
product
ACOG
organization
HIPAA Accelerator
other
CLIA-certified laboratory
organization
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