Episode 58: ASM Roundup - Day 1 with Dr Marinka Twilt

Around the Rheum with Drs. Daniel Ennis & Janet Pope23mApril 17, 2026

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AI-Generated Summary

At the 2026 Canadian Rheumatology Association Annual Scientific Meeting in Halifax, Dr. Daniel Ennis and Dr. Janet Pope deliver a live, on-site roundup with Dr. Marinka Twilt, Program Committee Chair, capturing Day 1’s most impactful moments. The episode reveals a stark gap in pediatric rheumatology research: while adult trials are abundant, pediatric studies remain limited to case series and cohort data, with no industry-sponsored clinical trials. Dr. Twilt highlights the growing recognition of autoinflammatory diseases like PFAPA and SERV—conditions that often persist into adulthood—underscoring the need for better pediatric-adult collaboration. A standout moment comes from the two-year follow-up of the SELECT GCA trial, showing upadacitinib maintained 70% remission at year two, challenging the assumption that treatment can be safely stopped after one year. The keynote by Dr. Elizabeth Volkman delivers a paradigm-shifting message: childhood trauma is a significant, underrecognized risk factor for autoimmune disease onset and chronic pain syndromes in adulthood. She advocates for integrating trauma-informed care into rheumatology, urging clinicians to ask about life history and validate patient experiences—something that can be done with low-cost, accessible tools like breathing exercises and yoga.

Key Takeaways
1

Pediatric rheumatology lacks industry-sponsored clinical trials—most research remains case series or cohort studies, limiting evidence-based treatment options.

2

Upadacitinib maintained 70% remission in GCA patients at two years, suggesting long-term treatment may be necessary to prevent flares after initial induction.

3

Childhood trauma is a significant, underrecognized risk factor for autoimmune disease and chronic pain syndromes in adulthood—clinicians should routinely screen for it.

4

Trauma-informed care improves patient outcomes: simple, low-cost interventions like breathing exercises, yoga, and walking can significantly enhance well-being and treatment adherence.

5

Rare diseases are often missed because clinicians rely too heavily on standard tests—biopsy, clinical history, and interdisciplinary dialogue are essential diagnostic tools.

…and 3 more takeaways available in PodZeus

Chapters
0:00
2 min

Welcome to ASM 2026 in Halifax

Hosts Dr. Daniel Ennis and Dr. Janet Pope introduce the live special episode from the Canadian Rheumatology Association’s 2026 Annual Scientific Meeting in Halifax, Nova Scotia, with sponsorship from Celtrion Healthcare and editorial oversight by an independent CRA committee.

2:00
3 min

Year in Review: Pediatric Gaps and Autoinflammation

There's no clinical trials. If we're lucky, they're cohort studies. Most of the time, they're case series.

Highlight
5:00
3 min

SELECT GCA Trial: Two-Year Follow-Up

The UPA continuation group had a 70% remission rate versus around 30% in the placebo group.

Highlight
8:00
4 min

Tough-to-Treat: A Misunderstood Term

We apparently still use this term also not very clearly with what we, like I would have expected or what maybe other people had expected.

Highlight
12:00
4 min

Clinical Pearls & Medical Mysteries: The Art of Diagnosis

You have to read the words. You have to talk to your other colleagues that are helping to co-manage or helping you.

Highlight
High-Impact Quotes
Many people that she sees with chronic autoimmune, especially she has a large scleroderma population, have had really bad childhood trauma, death of a loved one, separations of parents, abuse, et cetera.
Dr. Janet Pope16:51
Viral: 90.0
The UPA continuation group had a 70% remission rate versus around 30% in the placebo group.
Dr. Marinka Twilt5:34
Viral: 88.0
What can you do for you? That's where you can work as a team or they can feel more empowered, as she was saying, in their own care.
Dr. Marinka Twilt20:15
Viral: 87.0
Speakers

Hosts

Dr. Daniel EnnisDr. Janet Pope

Guest

Dr. Marinka Twilt
Topics Discussed
trauma-informed rheumatology95%upadacitinib in GCA93%pediatric rheumatology research92%giant cell arteritis treatment90%rare disease diagnosis88%patient empowerment in chronic illness87%clinical pearls and medical mysteries85%autoinflammatory diseases80%
People & Brands

Dr. Marinka Twilt

person

12xNeutral

Dr. Janet Pope

person

10xNeutral

Dr. Daniel Ennis

person

8xNeutral

Dr. Elizabeth Volkman

person

6xPositive

Canadian Rheumatology Association

organization

4xNeutral

Dr. Elizabeth Stringer

person

3xNeutral

Dr. Alex Legger

person

2xNeutral

Celtrion Healthcare

organization

2xPositive

Dr. Prutin-Raman

person

2xNeutral

Dr. Lisa Christopher Stein

person

2xNeutral

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