Ask Your Doctor About

99% Invisible32mMay 12, 2026

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AI-Generated Summary

This episode of 99% Invisible dives into the surprising art and science behind pharmaceutical brand names, exploring why drugs like Viagra, Lunesta, and Imdeltra sound so bizarre and otherworldly. Host Sean Cole investigates the naming process with Scott Piergrosi of the Brand Institute, the company responsible for naming over 75% of new drugs, and Arlene Tech, a legendary drug name creator and poet who named Viagra. The episode reveals that these names aren't random—they're the result of rigorous, creative, and often poetic processes designed to be trademarkable, distinct, and safe under FDA regulations. Constraints like avoiding look-alike/sound-alike names, preventing misleading claims, and ensuring visual differentiation through letter shapes (ascending and descending letters) drive the strange, complex names we see. Yet beneath the jargon lies a surprising layer of creativity: names are crafted to 'sing,' to feel good in the mouth, and to evoke emotional resonance—like Tujejo, which conveys the freedom of long-lasting insulin. The episode ultimately reframes drug names not as marketing gimmicks, but as linguistic artistry shaped by science, regulation, and emotional storytelling.

Key Takeaways
1

Drug names are crafted under strict FDA rules to avoid misleading claims, look-alike/sound-alike confusion, and ensure visual distinctiveness.

2

The naming process involves teams brainstorming hundreds of options, using poetic devices, linguistic patterns, and even haiku-like rhythm to create memorable, pronounceable names.

3

Names like Viagra and Tujejo carry deep narrative meaning—evoking freedom, longevity, and emotional resonance—beyond just branding.

4

The goal is not just to be unique, but to be 'singable'—a name that flows naturally in conversation and feels right when spoken.

5

Despite their oddity, these names are the result of a high-stakes creative process balancing regulation, marketability, and emotional impact.

Chapters
0:00
2 min

The Power of a Name: GoFundMe's Call to Action

A promotional segment for GoFundMe encourages listeners to start a fundraising campaign for causes they care about, emphasizing ease, creativity, and community impact.

1:48
3 min

The Mystery of Drug Brand Names

Sean Cole introduces the central question: why do pharmaceutical brand names sound like characters from Star Trek? He sets up the episode’s exploration of the creative and regulatory forces behind these names.

5:00
5 min

The Brand Institute: Naming 75% of New Drugs

Scott Piergrosi, head of creative at the Brand Institute, explains how his team generates 300–500 name ideas per drug, using AI, linguistic patterns, and creative exercises to find viable, unique names.

10:00
8 min

From Poetry to Pharmacology: The Art of Naming

When you're naming drugs and you've named a lot of them, how did it feel when it was finally out on the market? No, what the feeling was, not then. It was when I originally came up with the name and wrote it down on paper and I said, this is going to be a good one. That's when I had the good feeling. It was like a mental orgasm.

Highlight
18:00
7 min

Regulation and the Science of Distinction

The episode unpacks FDA rules that shape drug names: no exaggerated claims, no look-alike/sound-alike risks (like the Lasix/Losec mix-up), and visual differentiation through ascending/descending letters to prevent medication errors.

High-Impact Quotes
When you're naming drugs and you've named a lot of them, how did it feel when it was finally out on the market? No, what the feeling was, not then. It was when I originally came up with the name and wrote it down on paper and I said, this is going to be a good one. That's when I had the good feeling. It was like a mental orgasm.
Arlene Tech30:13
Viral: 90.0
You should read your haikus out loud when you're writing them, she says, and you should do the same with a drug name. It has to feel like it fits in your mouth. It has to flow in conversation.
Arlene Tech27:04
Viral: 85.0
The name? No, a bird. It hit my windshield. When that happened, I got depressed. Not you, Cisco. Yeah, even me. But as soon as I got depressed, I got undepressed because as I was cleaning the gleaming guts of that bird off my windshield, I thought of the name for the drug.
Kids in the Hall (in Brain Candy)4:56
Viral: 75.0
Speakers

Hosts

Roman MarsSean Cole

Guests

Scott PiergrosiArlene Tech
Topics Discussed
Pharmaceutical Brand Naming95%FDA Regulatory Constraints90%Linguistic Artistry and Poetry88%Creative Process in Naming85%Drug Safety and Medication Errors80%Emotional Resonance in Branding75%Marketing and Consumer Perception70%AI in Branding60%
People & Brands

Arlene Tech

person

15xPositive

Scott Piergrosi

person

12xPositive

Brand Institute

organization

10xPositive

FDA

organization

8xNeutral

Viagra

product

8xPositive

Tujejo

product

5xPositive

David Wood

person

4xPositive

Lunesta

product

4xPositive

Imdeltra

product

4xMixed

GoFundMe

organization

4xPositive

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